Key result
A subset of 9 fetal heart rate variability measures correlated with ileal macrophage activation and increased leakiness 1.5 days before tissue-level changes in a fetal sheep model of inflammation.
Why the study?
Can fetal heart rate variability detect incipient gut inflammation in a fetal sheep model of chorioamnionitis?
Can fetal heart rate variability detect incipient gut inflammation in a fetal sheep model of chorioamnionitis?
Fetal heart rate variability measures can detect macrophage activation and increased leakiness in the terminal ileum 1.5 days ahead of time in a fetal sheep model, suggesting potential for early noninvasive detection of necrotizing enterocolitis risk.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for early noninvasive fetal monitoring in chorioamnionitis; leaves open translation from sheep models to human neonates.
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Liu et al. (2016) studied Necrotizing enterocolitis (n=21). Lipopolysaccharide (IV) was evaluated on Correlation of fetal heart rate variability measures to markers of ileal inflammation. A subset of 9 fetal heart rate variability measures correlated with ileal macrophage activation and increased leakiness 1.5 days before tissue-level changes in a fetal sheep model of inflammation.
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