We describe a case of Acanthamoeba encephalitis with chronic lymphocytic leukemia (CLL) in the United States and summarize the Free-Living Ameba database to highlight CLL as the most common underlying malignancy for Acanthamoeba infections. CLL patients are more likely to have improved survival and nondisseminated cutaneous disease than those with other cancers.
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Persico et al. (2026) studied this question.
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