Short and Efficient Synthesis of Statine and Isostatine Derivatives

All articles of this category The preparation of Fmoc-(3 R ,4 S )-statine tert -butyl ester [ tert -butyl (3 R ,4 S )-4-(9-fluorenylmethoxycarbonylamino) -3-hydroxy-6-methylheptanoate] and the corresponding (3 S ,4 R ,5 S )-isostatine derivative from Fmoc-leucine and Fmoc-D-alloisoleucine respectively by sequential activation, ß-keto ester formation and reduction, is described.