The reformatsky reaction of 1‐acyl‐3,5‐dimethylpyrazoles. A convenient preparation of 4‐amino‐3‐oxoalkanoic acid derivatives

The conversion of N ‐acylpyrazoles into β‐keto esters was accomplished efficiently by the treatment with α‐bromo esters and zinc dust. Using this Reformatsky reaction of N ‐acylpyrazoles, 4‐(protected amino)‐3‐oxoalkanoic acid derivatives were conveniently prepared as the key intermediates in the synthesis of statines.