Immunohistochemical Evidence of a Sauvaginelike Immunoreactivity in Frog Retina Müller Cells

Using immunohistochemical techniques we found sauvagine-like immunoreactivity in the frog retina. Sauvagine-like immunoreactivity is seen in cells, the nuclei of which are localized in the middle of the inner nuclear layer. The cytoplasm is filled with sauvagine-like immunoreactive granules; the shape of this cell is very irregular, and it has numerous thin processes extending from the outer to the inner limiting membranes, filling all interneuronal space. These immunoreactive structures are much more numerous in the retinal periphery than in its central zone. These morphological and topographical characteristics led us to believe that the sauvaginelike immunoreactive structures are Miiller cells, a typical radial non-neuronal component in the retina.