Dynamics is an essential feature of supramolecular systems, and it's understanding will be central in achieving new chemical function. The methodology to obtain association and dissociation rate constants for fast binding of guests to host systems in real time is described. Examples are provided for binding of guests to cyclodextrins or bile salt aggregates with an emphasis on the type of information and mechanistic insight that can only be uncovered from kinetic studies and is not apparent in thermodynamic investigations.
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Cornelia Bohne (2006) studied this question.
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