Answers are grounded in this paper and cite their sources.
An expedient and concise Ugi-based approach for the rapid assembly of pyrazin-2(1H)-one-based frameworks has been developed. This convergent approach encompasses skeletal, functional and stereochemical diversity, exhibiting an unusually high bond-forming efficiency as well as high structure and step economies. The method involves the use of readily available commercial reagents and is an example of the reconciliation of structural complexity with operational simplicity in a time- and cost-effective manner.
No takes yet. Share an insight, caveat, or question.
Azuaje et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: