Synthesis of 2,6-Dimethyl-6-(8-methyl-4-methylene-7-nonenyl)-2-cyclohexene-1-methanols from α-Santonin

Abstract α-Santonin was converted to 2,6-dimethyl-6-(8-methyl-4-methylene-7-nonenyl)-2-cyclohexene-1-methanols (1a and 1b). Both spectral data of 1a and 1b were found to be different from those reported for magydar-2,10(20),13-trien-17-ol, a diterpene isolated from Magydaris panacifolia (Vahl) Lange. This indicates that the structure of the natural diterpene should be revised; the structure was later revised to t-6-hydroxymethyl-1, t-3-dimethyl-t-2-(3-methyl-2-butenyl)-3-(4-methyl-3-pentenyl)-r-1-cyclohexanol.