Key result
Older patients with metastatic cancer who received chemotherapy had a higher rate of hospitalization for any cause (92% vs 83%) and for likely treatment toxicity (51% vs 34%) compared to matched nonrecipients.
Why the study?
Does chemotherapy increase the risk of hospitalization in older adults with advanced cancer?
Cohort (n=36,972)
Yes
Does chemotherapy increase the risk of hospitalization in older adults with advanced cancer?
In older adults with advanced cancer, chemotherapy is associated with a significantly increased risk of hospitalization, including admissions for likely treatment toxicity.
May warrant caution in chemotherapy decisions for older adults; leaves open causality and net benefit in randomized trials.
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O’Neill et al. (2016) conducted a cohort in Metastatic cancer (n=36,972). Chemotherapy vs. No chemotherapy was evaluated on Hospital admission for any cause. Older patients with metastatic cancer who received chemotherapy had a higher rate of hospitalization for any cause (92% vs 83%) and for likely treatment toxicity (51% vs 34%) compared to matched nonrecipients.
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