Hopkins (1) has recently isolated a cell constituent, glutathione, which would appear to play an important part in the dynamic oxidation and reduction processes in the tissues. The substance is a dipeptide of cystein and glutaminic acid, but the exact position of the peptide linkage has not yet been determined. For convenience the formula may be written G . SH, where G represents the residue of the cystein molecule linked with glutaminic acid. On oxidation the substance is converted to the disulphide form G . S . S . G in a manner strictly analogous to the conversion of cystein to cystine.
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Dixon et al. (1923) studied this question.