Trimethoprim-Induced Aseptic Meningitis

ASEPTIC meningitis has been described in association with the administration of anti-inflammatory drugs, including ibuprofen, sulindac and tolmetin sodium, and azathioprine.1-4Most, but not all, of the patients reported have had either systemic lupus erythematosus (SLE) or mixed connective-tissue disease.5,6Sulfamethizole-induced meningitis and pancreatitis have been described in a patient who was ostensibly free of underlying chronic disease.7More recently, aseptic meningitis has been associated with the use of trimethoprim-sulfamethoxazole.8This report describes a patient with Sjögren's syndrome who had four episodes of aseptic meningitis temporally related to the use of trimethoprim-sulfamethoxazole, and a single episode of aseptic meningitis following the use of trimethoprim alone. Report of a Case First Admission.— A 61-year-old diabetic woman was hospitalized in June 1979 with a two-day history of fever, headache, nausea, and myalgias. Three years previously, she had complained of hair loss, arthralgias, and dryness of the eyes and