Key result
Hydroflumethiazide therapy did not significantly alter maximal glucose uptake (12.6 vs 12.0 mg/kg/min) or basal glucose output (2.97 vs 3.63 mg/kg/min) in insulin-dependent diabetics.
Why the study?
Does short-term hydroflumethiazide therapy alter peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetics?
Population
11 insulin-dependent diabetics
Comparison
Hydroflumethiazide 75 mg daily for 2 weeks vs Baseline
Design
Cohort
Follow-up
2 weeks
Authors
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Short-term hydroflumethiazide shows no effect on insulin sensitivity in IDDM; leaves open long-term effects and broader populations.
Does short-term hydroflumethiazide therapy alter peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetics?
Short-term thiazide therapy does not appear to impair peripheral or hepatic insulin sensitivity in insulin-dependent diabetics.
Schmitz et al. (1986) studied Insulin-dependent diabetes mellitus (n=11). Hydroflumethiazide vs. Baseline (before therapy) was evaluated on Glucose uptake and basal glucose output. Hydroflumethiazide therapy did not significantly alter maximal glucose uptake (12.6 vs 12.0 mg/kg/min) or basal glucose output (2.97 vs 3.63 mg/kg/min) in insulin-dependent diabetics.
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