The presence of the second component of human complement in synovial fluid was demonstrated by a stoichiometric titration using EAC′lagp4gp cells; fourth component and a moiety of third component were identified by immunoelectrophoresis using specific antiserum. The concentration of total hemolytic complement, C′2, and C′4 was strikingly diminished in synovial fluid from patients with rheumatoid arthritis compared to their concentration in synovial fluid from patients with traumatic, degenerative or gouty effusions. These findings suggest that reduction in total complement activity was due to activation of C′1 with subsequent utilization of its substrates, C′2 and C′4.
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Fostiropoulos et al. (1965) studied this question.
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