Key result
Dense [125I]-ET-1 binding was predominantly localized to ETA receptors on smooth muscle cells of neural microvessels and the perineurium in human peripheral nerves.
The study identifies regions where locally-released ET-1 may affect neural vascular perfusion, suggesting a potential pathophysiological role in conditions such as diabetic neuropathy.
May implicate ET-1 in neural perfusion; leaves open a role in diabetic neuropathy pending clinical validation.
[125I]-ET-1 binding to human peripheral nerve was studied using a combination of in vitro autoradiography and immunohistochemistry. Dense binding was predominantly to ETA receptors located on smooth muscles cells of the neural microvessels and the perineurium. These results identify regions where locally-released ET-1 may affect neural vascular perfusion and play a pathophysiological role in certain conditions, such as diabetic neuropathy.
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Dashwood et al. (1997) studied this question. [125I]-ET-1 binding was evaluated on Localization of [125I]-ET-1 binding sites. Dense [125I]-ET-1 binding was predominantly localized to ETA receptors on smooth muscle cells of neural microvessels and the perineurium in human peripheral nerves.
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