Key result
In patients with moderate to severe renal insufficiency, the optimal BNP cut-off for diagnosing systolic heart failure was 829 pg/mL (accuracy 68%, sensitivity 66%, specificity 70%; p<0.001).
Why the study?
Is B-type natriuretic peptide (BNP) measurement a useful test for diagnosing systolic heart failure in patients with moderate to severe renal insufficiency?
Population
433 patients with systolic heart failure or moderate to severe renal insufficiency, mean age 67.6±12, 49%…
Design
Cross-sectional
Authors
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Higher BNP thresholds may be considered in renal insufficiency but modest accuracy cautions against sole reliance; leaves open prospective validation of refined cut-offs.
Observational (n=433)
Is B-type natriuretic peptide (BNP) measurement a useful test for diagnosing systolic heart failure in patients with moderate to severe renal insufficiency?
Effect estimate: accuracy 68%, sensitivity 66%, specificity 70%
p-value: p=<0.001
In patients with moderate to severe renal insufficiency, a higher BNP cut-off (829 pg/mL) is required to diagnose systolic heart failure, and the overall diagnostic accuracy is relatively low.
Wang et al. (2005) conducted an observational in Systolic heart failure and/or moderate to severe renal insufficiency (n=433). B-type natriuretic peptide (BNP) measurement was evaluated on Optimal cut-off point of BNP for the diagnosis of systolic HF in patients with RI (accuracy 68%, sensitivity 66%, specificity 70%, p=<0.001). In patients with moderate to severe renal insufficiency, the optimal BNP cut-off for diagnosing systolic heart failure was 829 pg/mL (accuracy 68%, sensitivity 66%, specificity 70%; p<0.001).
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