Amidine Sulfonamides and Benzene Sulfonamides: Synthesis and Their Biological Evaluation

New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT‐IR, ESI‐MS, 1 HNMR, and 13 CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely, S. aureus, B. subtilis , and E. coli , and fungi, namely, A. flavus, A. parasiticus , and A. sp. The antibacterial and antifungal activities have been determined by measuring MIC values ( μ g/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 3b , 9a , and 9b have most potent activity against S. aureus, A. flavus, and A. parasiticus , respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 μ g/mL. In contrast, all the compounds were totally inactive against the A. sp. except 10b and 15b to show activity to some extent.