Key result
Enterovirus 71 infection of human colorectal cells altered the expression of genes involved in critical pathways, including the immune and stress responses.
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Transcriptomic profiling of EV71-infected human colorectal cells reveals altered expression in immune and stress response pathways, providing insights into viral pathogenesis.
Enterovirus 71 (EV71) is one of the main etiological agents for Hand, Foot and Mouth Disease (HFMD) and has been shown to be associated with severe clinical manifestation. Currently, there is no antiviral therapeutic for the treatment of HFMD patients owing to a lack of understanding of EV71 pathogenesis. This study seeks to elucidate the transcriptomic changes that result from EV71 infection. Human whole genome microarray was employed to monitor changes in genomic profiles between infected and uninfected cells. The results reveal altered expression of human genes involved in critical pathways including the immune response and the stress response. Together, data from this study provide valuable insights into the host-pathogen interaction between human colorectal cells and EV71.
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Lui et al. (2014) studied Enterovirus 71 (EV71) infection. Enterovirus 71 (EV71) infection vs. Uninfected cells was evaluated on Transcriptomic changes / genomic profiles. Enterovirus 71 infection of human colorectal cells altered the expression of genes involved in critical pathways, including the immune and stress responses.
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