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January 1, 2001The Journal of AntibioticsOpen Access

Cytokine Production Inhibitors Produced by a Fungus, Oidiodendron griseum.

Katsuomi Ichikawa Hideo Hirai MASARU ISHIGURO Takahito Kambara Yoshinao Kato Yoon Jeong Kim Yasuhiro Kojima YASUE MATSUNAGA Hiroyuki Nishida YUKIO SHIOMI Nobuji Yoshikawa LLANG HSIUNG HUANG Nakao Kojima

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Abstract

A series of diterpenes were isolated from the fermentation broth of a fungus, Oidiodendron griseum CL37215. The diterpenes were identified as LL-Z1271alpha, LL-Z1271gamma, CJ-14,445, PR 1388, CJ-14,604 and a new diterpene, CJ-14,515. They inhibited both lipopolysaccharide-induced interleukin-1beta and tumor necrosis factor-alpha production in human whole blood with IC50s of the range from 0.049 to 100 microM.

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Ichikawa et al. (2001) studied this question.

synapsesocial.com/papers/6a978e9a0fc5fb4479fac658 https://doi.org/10.7164/antibiotics.54.697

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