Key result
A 1% Panicum miliaceum L. extract-supplemented diet significantly reduced serum triglycerides by 19.5% and total cholesterol by 16.2% in obese ob/ob mice compared to a normal diet.
Why the study?
Does Panicum miliaceum L. extract (PME) reduce hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice?
Population
40 male leptin-deficient (C57BL/6J-ob/ob) mice and C57BL/6J lean mice controls, 5 weeks of age.
Comparison
Panicum miliaceum L. extract supplemented in… vs AIN-93G control diet (normal diet) without PME.
Design
Preclinical, divided into four groups based on their body weights
Follow-up
4 weeks
Authors
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Hypothesis-generating for PME in obese hyperlipidemia; human trials needed before clinical consideration.
Does Panicum miliaceum L. extract (PME) reduce hyperlipidemia and hepatic lipid accumulation in C57BL/6J-ob/ob mice?
Absolute Event Rate: 114.98% vs 142.84%
p-value: p=<0.05
A 1% Panicum miliaceum L. extract diet ameliorates obesity-induced hyperlipidemia, hepatic lipid accumulation, and inflammation in ob/ob mice by regulating fatty acid metabolism genes.
Park et al. (2011) studied Obesity and hyperlipidemia (n=40). Panicum miliaceum L. extract (PME) vs. Normal diet (AIN-93G) was evaluated on Serum triglyceride levels (mg/dL) (p=<0.05). A 1% Panicum miliaceum L. extract-supplemented diet significantly reduced serum triglycerides by 19.5% and total cholesterol by 16.2% in obese ob/ob mice compared to a normal diet.
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