The Hedgehog family of signaling molecules is essential for a variety of developmental processes. In this issue, Porter et al . ( p. 255 ) identify the lipid adduct to Sonic hedgehog —necessary for its function in vertebrate head development—as cholesterol. In his Perspective, Martin discusses how this new function for cholesterol may be the first example of a modification used by many signaling molecules.
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Gail R. Martin (1996) studied this question.
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