Freeze-dried B.C.G. Vaccine

ConclusionsThe Danish B.C.G. vaccine has proved uniformly satisfactory for use, in appropriate dosage, in newborn infants.It suffers, however, from the defects inhierent in any living liquid vaccine and it produces complica- tions of a minor, but nevertheless undesirable, nature in a small proportion of cases.A new British freeze-dried vaccine has been found to be equally effective when given in suitable doses.The clinical effects of such a vaccine have been shown to vary according to the number of viable organisms injected.Since accuracy of bacillary dosage is now a practical possibility, it is probable that satisfactory free-dried vaccines with none of the disadvantages of the liquid preparations may soon replace them.We are Indebted to Dr. J. Ungar and Dr. P. W. Muggleton for their help and advice throughout these investigations.