Coupled microreactors allow fast, continuous, multistep synthesis of the title compound. Thus, grafting with APTES is carried out in microreactor I, mixing with sol–gel TEOS and APTES labeled with Rhodamine B isothiocyanate (RITC) in II, and coating in III. This technique opens the way to developing a lab-on-a-chip platform for nanoparticle synthesis.
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Abou‐Hassan et al. (2009) studied this question.
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