A 66-year-old lower-extremity amputee with an acute femoral artery occlusion was treated with low-dose (10000 units/h) percutaneous constant-infusion streptokinase. At 48 hours after initiation of therapy, the patient experienced adult respiratory distress syndrome and died. A postmortem examination confirmed the diagnosis; laboratory studies reflected an increased level of fibrinolytic split products, thrombocytopenia, and a low level of fibrinogen.
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Morris D. Kerstein (1986) studied this question.
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