Effect of Heparin on the One-Stage Prothrombin Time

Diagnosis and Treatment1 June 1967Effect of Heparin on the One-Stage Prothrombin TimeSource of Artifactual "Resistance" to Prothrombinopenic TherapyKENNETH M. MOSER, M.D., F.A.C.P., GEORGE C. HAJJAR, M.D.KENNETH M. MOSER, M.D., F.A.C.P.Search for more papers by this author, GEORGE C. HAJJAR, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-6-1207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe medical subspecialist may become so familiar with certain phenomena in his area of interest that he may drift into the assumption that these phenomena are common knowledge among his colleagues. Such an assumption often inhibits, quite unintentionally, the dissemination of clinically important information to the practicing physician. This report deals with one such situation: the effect of heparin on the one-stage prothrombin time. As will be documented here, prolongation of the prothrombin time by heparin introduces a frequently unrecognized variable into the proper establishment and maintenance of anticoagulant therapy with prothrombinopenic (coumarin-type) agents.Our interest in this problem was...References1. HOUGIE C: Fundamentals of Blood Coagulation in Clinical Medicine. McGraw-Hill Book Co., Inc., New York, 1963. Google Scholar2. MACMILLANMUSTARD RLJF (editors): Anticoagulants and Fibrinolysins: International Symposium. Lea & Febiger, Philadelphia, 1961. Google Scholar3. DOUGLAS AS: Anticoagulant Therapy. F. A. Davis Co., Philadelphia, 1962. Google Scholar4. DEYKINWESSLERREIMER DSSM: Evidence for an antithrombotic effect of Dicumarol. Amer. J. Physiol. 199: 1161, 1960. CrossrefMedlineGoogle Scholar5. SISEMOSCHOSGAUTHIERBECKER HSCBJR: The risk of interrupting long-term anticoagulant treatment. A rebound hypercoagulable state following hemorrhage. Circulation 24: 1137, 1961. CrossrefMedlineGoogle Scholar6. MUSTARDMURPHYROSWELLDOWNIE JFEAHCH: Factors influencing thrombus formation in vivo. Amer. J. Med. 33: 621, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: KENNETH M. MOSER, M.D., F.A.C.P.; GEORGE C. HAJJAR, M.D.Affiliations: Washington, D. C.From the Department of Medicine, Georgetown University School of Medicine, and the Enzyme Research Laboratory, District of Columbia General Hospital, Washington, D. C.This study was supported in part by grant HE-6263, National Institutes of Health, Bethesda, Md., and by a grant from the Washington Heart Association, Washington, D. C.Requests for reprints should be addressed to Kenneth M. Moser, M.D., Georgetown University Hospital, Pulmonary Division, Room 2231, 3800 Reservoir Rd., NW, Washington, D. C. 20007. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVariation in the Prothrombin-Time Ratio during Oral AnticoagulationEnoxaparin: The Low-Molecular-Weight Heparin for Prevention of Postoperative Thromboembolic ComplicationsEvaluierung eines neuartigen Thromboplastins auf der Basis von rekombinantem humanem Tissue Factor und synthetischen PhospholipidenAprotinin: The ideal anti-coagulant?Heparin degradation by a novel microbial heparinaseSTUDIES ON THE MEDICAL TREATMENT OF DEEP VEIN THROMBOSISDipyrone-ethylbiscoumacetate interaction in manHeparin, brain thromboplastin and the insensitivity of the prothrombin time to heparin activityIncidence of Bleeding Complications in Patients on Intermittent IV Heparin TherapyDrugs Known to React with Coumarin-Type Anticoagulants — RevisedAnticoagulantsDie partielle ThromboplastinzeitDrugs Affecting Therapy with AnticoagulantsWarfarin TherapyFemoral Nerve Entrapment Secondary to a Heparin HematomaGEORGE P. SUSENS, M.D., C. G. HENDRICKSON, M.D., M. J. MULDER, M.D., BRUCE SAMS, M.D. 1 June 1967Volume 66, Issue 6Page: 1207-1213KeywordsAnticoagulant therapyEnzymesHeartHeparinHospital medicineLongitudinal studiesProthrombin timeResearch laboratoriesSub-specialty care ePublished: 1 December 2008 Issue Published: 1 June 1967 PDF downloadLoading ...