Serum Cholinesterase in Hepatic and Neoplastic Diseases: A Preliminary Report

Article1 December 1954SERUM CHOLINESTERASE IN HEPATIC AND NEOPLASTIC DISEASES: A PRELIMINARY REPORTDAVID W. MOLANDER, M.S., M.D., MAX M. FRIEDMAN, Ph.D., JOHN S. LADUE, M.D., Ph.D., F.A.C.P.DAVID W. MOLANDER, M.S., M.D.Search for more papers by this author, MAX M. FRIEDMAN, Ph.D.Search for more papers by this author, JOHN S. LADUE, M.D., Ph.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-6-1139 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe purpose of this preliminary report is to describe a new colorimetric method to determine serum cholinesterase activity. The results of this enzyme activity for 110 normal patients, 57 patients with liver disease of multiple etiology and 20 whose liver dysfunction was presumably due to metastatic disease are presented. The possible usefulness of serum cholinesterase as a test of parenchymal liver disease is discussed in relation to the other standard liver function tests.METHODSThe method used in determining serum cholinesterase is an adaptation of that originally developed by Michel,1but employs a colorimeter rather than potentiometer for measurements....Bibliography1. Michel HO: An electrometric method for the determination of red blood cells and plasma cholinesterase activity, J. Lab. and Clin. Med. 34: 1564, 1949. Google Scholar2. Michaelis L: Diethylbarbiturate buffer, J. Biol. Chem. 87: 33, 1950. CrossrefGoogle Scholar3. MalloyEvelyn HTKA: The determination of bilirubin with the photoelectric colorimeter, J. Biol. Chem. 119: 481, 1937. CrossrefGoogle Scholar4. DucciWatson HCJ: The quantitative determination of serum bilirubin with special reference to prompt reacting and the chloroform soluble types, J. Lab. and Clin. Med. 30: 293, 1945. Google Scholar5. 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AntipolSchifrinTuckman WAL: Cholinesterase activity of human sera with special reference to hyperthyroidism, Proc. Soc. Exper. Biol. and Med. 36: 46, 1937. CrossrefGoogle Scholar12. AntipolTuckmanSchifrin WLH: Decreased cholinesterase activity of serum in jaundice and biliary disease, Proc. Soc. Exper. Biol. and Med. 38: 363, 1938. CrossrefGoogle Scholar13. VorhausScudamoreGabuadaMoreyMaloneyKark LJHHGJGRMARM: Serial serum cholinesterase determination in liver disease, J. Lab. and Clin. Med. 33: 1475, 1948. MedlineGoogle Scholar14. Farber M: Serum cholinesterase in disease, Acta med. Scandinav. 114: 59, 1943. CrossrefGoogle Scholar15. VorhausScudamoreKark LJHHRM: Measurement of serum cholinesterase activity in the study of diseases of the liver and biliary systems, Gastroenterology 15: 304, 1950. CrossrefMedlineGoogle Scholar16. BrauerRoot RWMA: Effect of carbon tetrachloride induced liver injury upon the acetylcholine hydrolyzing activity of the blood plasma of the rat, J. Pharmacol. and Exper. Therap. 88: 109, 1946. MedlineGoogle Scholar17. WescoeHuntRikerLitt WCCCWSIC: Regeneration rate of serum cholinesterase in normal individuals and patients with liver damage, Am. J. Physiol. 149: 549, 1947. CrossrefMedlineGoogle Scholar18. Farber M: Relationship between serum cholinesterase and serum albumin, Acta. med. Scandinav. 114: 72, 1943. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication February 26, 1954.From the Pack Medical Group, New York City. This investigation was supported by the Lillia Babbitt Hyde Foundation and the Pack Medical Foundation. 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WHITE, M.D., F.A.C.P.Serum Enzymes in Hepatic Disease�ber Fermentaktivit�tsbestimmungen im Serum beim kongenitalen und erworbenen h�molytischen IkterusRenale Fermentausscheidung bei ProteinurieSpezifischer Nachweis von Vergiftungen mit Alkylphosphaten (E 600, E 605, Systox) in Blut und Hirngewebe mit Hilfe eines fermentreaktivierenden Antidots (Pyridin-Aldoxim-Methjodid, PAM)Die Glutamins�ure-Brenztraubens�ure-Transaminase bei LeberkrankheitenStudies of Cholinesterase ActivityDie Bestimmung der Serumcholinesterase an der LeicheDie Veränderungen des Hirnstrombildes bei malignen Hämoblastosen.Die Veränderungen des Hirnstrombildes bei malignen HämoblastosenCase 41131The Normal Variation of Human Blood Cholinesterase Activity. 1 December 1954Volume 41, Issue 6Page: 1139-1151KeywordsEnzymesEtiologyLiver diseasesLiver function tests ePublished: 1 December 2008 Issue Published: 1 December 1954 PDF downloadLoading ...