An efficient and mild vinylation of O-, S-, and N-nucleophiles is reported. Copper(I) iodide/ethyl 2-oxocyclohexanecarboxylate is used as the catalytic system. The protocol tolerates a broad range of functional groups on the substrates, and gives the corresponding aryl styryl ethers, aryl styryl sulfides, and N-styrylimidazoles in moderate to excellent yields as well as with good stereoselectivity.
No takes yet. Share an insight, caveat, or question.
Bao et al. (2008) studied this question.