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Previous work has shown that animal and plant tissues are able to synthesize branched chain fatty acids such as P-hydroxy-P-methylglutaric acid,l ,&hydroxyisovaleric acid, and p ,/?-dimethylacrylic acid from smaller precursors such as acetic acid (l-7).This synthetic pathway appears to involve the following reactions wherein it is assumed that all the acids are activated as acyl CoA derivatives.(1) iI BCHI-COOH + CHI-C-CHz-COOH
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Harry Rudney (1957) studied this question.
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