Key result
Zoniporide administered before extracorporeal circulation improved postresuscitation left ventricular ejection fraction (0.57 vs 0.29, p<0.05) and cardiac index in a pig model of ventricular fibrillation.
Why the study?
Does zoniporide improve myocardial energy metabolism and postresuscitation function in a pig model of ventricular fibrillation?
RCT (n=16)
Randomized
Does zoniporide improve myocardial energy metabolism and postresuscitation function in a pig model of ventricular fibrillation?
Answers are grounded in this paper and cite their sources.
In a pig model of ventricular fibrillation, NHE-1 inhibition with zoniporide preserves left ventricular compliance and minimizes postresuscitation myocardial dysfunction through benefits on energy metabolism.
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Ayoub et al. (2007) conducted an RCT in Ventricular fibrillation (n=16). Zoniporide vs. Vehicle control was evaluated on Postresuscitation left ventricular ejection fraction (p=<.05). Zoniporide administered before extracorporeal circulation improved postresuscitation left ventricular ejection fraction (0.57 vs 0.29, p<0.05) and cardiac index in a pig model of ventricular fibrillation.
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