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Dissociated cells from embryonic mouse brain reassociate in rotation culture to form highly organized aggregates. Electron microscopic observations of aggregates show the presence of synapses that mature and increase in number during culture. Apparent myelination of axons is observed in the aggregates after 5 weeks of culture. Thus, brain cell aggregates perform two highly specialized morphological events that are characteristic of mouse brain differentiation.
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Seeds et al. (1971) studied this question.
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