Key result
Irbesartan significantly reduced the mean summed stress score (11 vs 13.2, P=0.003) and mean size of perfusion defects (15.3% vs 17.8%, P=0.01) after dipyridamole stress in patients with CAD.
Why the study?
Does irbesartan reduce the extent and severity of dipyridamole stress-induced myocardial perfusion defects in patients with CAD?
Does irbesartan reduce the extent and severity of dipyridamole stress-induced myocardial perfusion defects in patients with CAD?
Absolute Event Rate: 11% vs 13.2%
p-value: p=0.003
Irbesartan masks dipyridamole stress-induced myocardial perfusion defects, indicating that AT1 receptor blockers should be withheld prior to stress myocardial perfusion scintigraphy.
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Irbesartan was associated with reduced dipyridamole stress perfusion defects on MPI; hypothesis-generating for ARB masking effects, prospective validation required before practice change.
Altun et al. (2004) studied Coronary artery disease (CAD) (n=13). Irbesartan vs. Baseline (before irbesartan administration) was evaluated on Mean summed stress score (p=0.003). Irbesartan significantly reduced the mean summed stress score (11 vs 13.2, P=0.003) and mean size of perfusion defects (15.3% vs 17.8%, P=0.01) after dipyridamole stress in patients with CAD.
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