A novel “methylation” takes place in the biosynthesis of the antibiotic fosfomycin: apparently a methyl group from L-methionine adds to phosphonoacetaldehyde (1) as “CH” to provide (S)-2-hydroxypropylphosphonic acid (2). In contrast, (S)-adenosylmethionine transfers formally CH in a different manner.
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Friedrich Hammerschmidt (1994) studied this question.
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