seemed somewhat unnecessary when one was primarily attempting to determine the incidence of diarrhoea in a large number of patients.Both trials showed the incidence of diarrhoea to be halved in the patients receiving talampicillin and these results were shown to be statistically significant (P < 0-02 in both studies).Dr Grant is perfectly entitled to express his personal opinion of these antibiotics, but other clinicians appear to have come to a different conclusion and amoxycillin is now very widely used in both hospital and general practice in this country and overseas.Finally, I am sure that Dr Grant would be the first to appreciate that he is getting better value for money when he provides drugs that are well absorbed rather than those that, for the most part, go down the drain.
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Davies et al. (1977) studied this question.