Multipurpose sugar silanes Carbohydrate-derived silane reagents are utilized as the reductant for nickel-catalyzed aldehyde-alkyne reductive couplings, followed immediately by intramolecular glycosylation of the newly formed protected hydroxyl The approach, illustrated in the catalyzed conversion of aldehydes and alkynes to glycosylated allylic alcohols, enables the assembly of the carbon-carbon framework and stereochemical features of an aglycone while simultaneously establishing the site of glycosylation.
No takes yet. Share an insight, caveat, or question.
Partridge et al. (2013) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: