Effect of Saffron Extracts on Reproductive Function

Saffron (Crocus sativus L.), a historically valued medicinal plant, has garnered modern scientific interest due to its diverse bioactive compounds and therapeutic potential.Rich in crocin, crocetin, picrocrocin, and safranal, saffron exhibits antioxidant, anti-inflammatory, antidepressant, and neuroprotective effects.Recent clinical studies have demonstrated its effectiveness in improving symptoms of premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), menopausal discomfort, and female sexual dysfunction.Standardized extracts like Affron® have been shown to enhance mood, reduce anxiety and depression, and improve sleep and hormonal symptoms in women, with minimal side effects.Despite its safety at therapeutic doses, dosage control remains essential to avoid toxicity.This review synthesizes the pharmacological properties and clinical evidence supporting saffron's role in women's health, underscoring its potential as a safe, non-hormonal, plant-based treatment for various gynecological and psychological conditions.