The Treatment of Lobar Pneumonia With Concentrated Antipneumococcus Serum

During the past two years we have continued our studies on the specific treatment of lobar pneumonia at Bellevue Hospital. This work has been both clinical and experimental. Since the fall of 1926, our interest has been largely confined to investigation of the immunologic properties and the therapeutic value of concentrated antipneumococcus serum. The serum that has particularly engaged our attention is a derivative of antipneumococcus serum prepared according to the method of Felton.1 PREPARATION AND STANDARDIZATION OF SERUM The actual technic of the preparation of this serum has been thoroughly described by Felton in a series of articles which he has published in various periodicals. The original antipneumococcus horse serum is concentrated in both the monovalent and the polyvalent forms. Felton's method of concentration may be briefly described as follows.2 One liter of serum is slowly poured into 15 liters of agitated, cooled distilled water, and the