Key result
The overall estimated prevalence of pre-existing AF and incidence of AF following liver transplantation are 5.4% and 8.5%, respectively, and are potentially associated with poor clinical outcomes.
Why the study?
Does pre-existing or post-operative atrial fibrillation impact clinical outcomes in liver transplant recipients?
Meta-Analysis
Does pre-existing or post-operative atrial fibrillation impact clinical outcomes in liver transplant recipients?
p-value: p=< 0.05
Pre-existing and new-onset atrial fibrillation are common in liver transplant recipients (5.4% and 8.5% respectively) and are associated with poor clinical outcomes.
Pre-existing and new-onset AF are associated with higher post-liver transplant mortality and complications; leaves open whether targeted management improves outcomes.
AIM: To assess prevalence of pre-existing atrial fibrillation (AF) and/or incidence of AF following liver transplantation, and the trends of patient's outcomes overtime; to evaluate impact of pre-existing AF and post-operative AF on patient outcomes following liver transplantation. METHODS: A literature search was conducted utilizing MEDLINE, EMBASE and Cochrane Database from inception through March 2018. We included studies that reported: (1) prevalence of pre-existing AF or incidence of AF following liver transplantation; or (2) outcomes of liver transplant recipients with AF. Effect estimates from the individual study were extracted and combined utilizing random-effect, generic inverse variance method of DerSimonian and Laird. The protocol for this meta-analysis is registered with PROSPERO (International Prospective Register of Systematic Reviews, No. CRD42018093644). RESULTS: < 0.05). CONCLUSION: The overall estimated prevalence of pre-existing AF and incidence of AF following liver transplantation are 5.4% and 8.5%, respectively. Incidence of AF following liver transplant does not seem to decrease overtime. Pre-existing AF and new-onset AF are potentially associated with poor clinical outcomes post liver transplantation.
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Chokesuwattanaskul et al. (2018) conducted a meta-analysis in Liver transplantation and atrial fibrillation. Pre-existing or new-onset atrial fibrillation was evaluated on Prevalence of pre-existing AF and incidence of AF following liver transplantation (p=< 0.05). The overall estimated prevalence of pre-existing AF and incidence of AF following liver transplantation are 5.4% and 8.5%, respectively, and are potentially associated with poor clinical outcomes.
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