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-catechol coordination also significantly enhances the mechanical properties of the hydrogel network and optimizes its degradation profiles to match local osteogenesis. In addition, TBH gradually releases osteogenic bovine bone collagen peptides to promote mineralization through spontaneous degradation. These merits cooperatively improve bone regeneration in osteoporotic rat models, providing an approach for osteoporotic bone fracture healing in the clinic.
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Hao et al. (2026) studied this question.
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