Experiments were designed to further characterize the nature of suckling mouse cataract agent (SMCA). The agent is sensitive to heat, trypsin and ultraviolet inactivation, but is stable over the pH range 5.8 to 10. Penicillin, kanamycin, streptomycin and rifampin have no effect on the replication of the agent while BUdR, actinomycin D and hydroxyurea are inhibitory. By filtration the size of the infectious particle was determined to be between 200 and 500 nm. Ultra-structural studies upon infected allantoic fluids reveal unique particles not present in fluids infected with a series of RNA and DNA viruses.
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Schwartz et al. (1972) studied this question.