The role of newer synovial biomarkers in the diagnosis of periprosthetic infections

Introduction Periprosthetic joint infection has remained the most annihilating adversity and intriguing challenge confronting orthopaedic surgeons following joint arthroplasty procedures globally. The criticality of a surgeon’s decision in identifying an underlying infection prior to revision arthroplasties and in managing such situations appropriately can never be understated. The current article reviews the role of novel synovial fluid biomarkers, including Polymerase Chain Reaction, C-Reactive Protein, leukocyte enzymes and other multiple molecular markers in identifying early PJIs. Conclusion The current literature is extremely scarce on these newer modalities, and their role in standard clinical practice is still greatly dubious and debatable. The research in this subject has a long way ahead and is reckoned in future, to elucidate our perspective and outlook on such scenarios.