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Advances in tract-tracing and immunocytochemistry have shifted the understanding of central cardiorespiratory control from vasomotor centers to specific neuronal pathways.
Highlights the shift from the concept of 'vasomotor centres' to specific neuronal pathways in understanding central cardiorespiratory control.
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Shifts cardiorespiratory models from vasomotor centers to specific pathways; extends foundational concepts but leaves clinical translation open.
The last two decades have seen major changes in our understanding of the medullo-spinal circuitry, and neurotransmitters, involved in central cardiorespiratory control. With the advent of effective tract-tracing techniques, immunocytochemistry and various combinations of these methodologies, earlier ideas about ‘vasomotor centres’ have been superseded by descriptions of cardiorespiratory reflexes based on specific neuronal pathways (Chalmers and Pilowsky ‘92, Dampney ‘94).
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Pilowsky et al. (1997) conducted a review in Cardiorespiratory control mechanisms. Advances in tract-tracing and immunocytochemistry have shifted the understanding of central cardiorespiratory control from vasomotor centers to specific neuronal pathways.
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