Erythema Multiforme Following High Voltage Roentgen Therapy

GUIDO HOLZKNECHT1reported in 1903, from Löw's Sanatorium in Vienna, 5 cases of a generalized febrile illness associated with roentgen dermatitis. The first patient, a 50 year old woman irradiated for facial hirsutism, had fever and an "erythema" limited to the neck and upper portion of the trunk, in association with a moderately severe roentgen dermatitis of the irradiated areas. Case 2 consisted of a universal papular eruption, with fever, in an 8 year old boy irradiated for psoriasis of the scalp. The third case was that of a 20 year old girl, irradiated for facial hirsutism, who acquired a scarlatiniform eruption with fever. Case 4 occurred in a 5 year old boy with favus of the scalp and consisted of fever and a pruritic, generalized exanthem of small papules, with vesicles in some areas. The fifth case was that of a 50 year old woman with