Key result
High serum hs-CRP levels were significantly associated with increased odds of mobility problems (OR 1.66; 95% CI 1.03-2.66) and suicidal ideation (OR 2.48; 95% CI 1.23-4.99) in adults with MetS.
Why the study?
Is elevated serum hs-CRP associated with decreased quality of life and mental health problems in adults with metabolic syndrome?
Cross-Sectional (n=1,600)
Is elevated serum hs-CRP associated with decreased quality of life and mental health problems in adults with metabolic syndrome?
Elevated inflammation, indicated by high hs-CRP levels, is significantly associated with reduced quality of life and increased suicidal ideation in adults with metabolic syndrome.
May link inflammation to psychiatric burden in MetS; hypothesis-generating and requires longitudinal validation before clinical consideration.
Metabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relationships among inflammation, mental health, quality of life, and other diseases have been conducted. We investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels, as an indicator of inflammation, and the quality of life and psychiatric symptoms of Korean adults with MetS. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians conducted from January to December 2015. Data from 1600 participants were analyzed in this study. Quality of life was assessed using the EuroQol 5-dimension (EQ-5D) instrument. Serum hs-CRP levels showed a significant inverse correlation with the EQ-5D index of the overall quality of life. High serum hs-CRP levels were positively associated with mobility problems and suicidal ideation in adults with MetS (multivariate-adjusted odds ratio [OR] 1.66, 95% confidence interval [CI] 1.03–2.66, p = 0.036; and multivariate-adjusted OR 2.48, 95% CI 1.23–4.99, p = 0.011). These findings suggest that the elevated inflammatory status in MetS is associated with decreased quality of life and mental health problems. Further prospective studies are needed to confirm the impact of inflammation on the quality of life and mental health of adults with MetS.
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Kim et al. (2018) conducted a cross-sectional in Metabolic syndrome (n=1,600). High serum hs-CRP levels vs. Lower serum hs-CRP levels was evaluated on Mobility problems (OR 1.66, 95% CI 1.03-2.66, p=0.036). High serum hs-CRP levels were significantly associated with increased odds of mobility problems (OR 1.66; 95% CI 1.03-2.66) and suicidal ideation (OR 2.48; 95% CI 1.23-4.99) in adults with MetS.
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