Pd‐Catalyzed Stereospecific Azide Substitution of α,β‐Unsaturated γ,δ‐Epoxy Esters with Double Inversion of Configuration

Acyclic, cyclic, and optically active unsaturated γ,δ-epoxy esters are employed in a highly stereoselective synthesis of functionalized amino alcohols, amino acids, and α,α-disubstituted amino acids. The key step of the reaction sequence is a double inversion of configuration (see scheme).