Systematic review protocol outlines methods to evaluate complementary therapies in chronic plaque psoriasis, highlighting the need for rigorous evidence on non-conventional treatments.
Background: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). Objective: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). Methods: We investigated 221 participants with psoriasis and 718 ageand sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam. Logistic regression models adjusted for Framingham risk score (FRS) and C-reactive protein (hs-CRP) were built. CAC was included in the models as a binary variable with different cut off values. Results: Body-mass index, race, hypertension, HDL, LDL and hs-CRP were significantly associated with psoriasis presence and severity. Psoriasis severity was significantly associated with CAC (p = 0.04), particularly for very high CAC (>400) (p < 0.01). The OR for severe psoriasis and CAC >400 was 2.45 Tese Doutorado em andamento • Psoríase e Aterosclerose Subclínica avaliada pela Espessura Médio-Intimal nas Artérias Carótidas -IMTc por meio da
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Monson et al. (2014) studied this question.
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