Alkynes are carboxylated in a highly regio- and chemoselective manner in the presence of Ni(cod) 2, DBU, and CO 2 to give the carboxylated products in good yields. The reaction was carried out under very mild conditions (CO 2 1 atm, 0 °C) in the presence of a stoichiometric amount of alkynes, conjugated enynes, or diynes. The high selectivity observed in the reaction would be explained in terms of the stability and the reactivity of the intermediates.
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Saito et al. (1999) studied this question.
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