Key result
Prothrombin complex concentrate for warfarin reversal should be used only when the INR is at least 1.5 and the patient has major bleeding or requires a procedure within six hours.
Why the study?
When should blood products be used for the emergency reversal of warfarin anticoagulation?
When should blood products be used for the emergency reversal of warfarin anticoagulation?
Provides clinical criteria for the appropriate use of blood products in the emergency reversal of warfarin.
May inform selective PCC use in warfarin reversal; leaves open prospective validation of criteria.
Blood products, such as prothrombin complex concentrate, should be used only when the international normalized ratio (INR) is at least 1.5 and the patient has major bleeding (e.g., intracranial hemorrhage) or needs a procedure within six hours (e.g., repair of a ruptured aortic aneurysm or
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Lin et al. (2010) studied this question. Prothrombin complex concentrate for warfarin reversal should be used only when the INR is at least 1.5 and the patient has major bleeding or requires a procedure within six hours.
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