Cardiac remodeling markedly contributes to cardiovascular disease progression, emerging as a primary therapeutic target for heart failure of all causes. It is a crisismanagement response of an injured heart to counterbalance stress and salvage function through changes in composition and architecture. Although initially stabilizing,the changes cannot offset the impairment. Progressive remodeling results in ventricular hypertrophy, dilation, anda spherical geometry. The evolving cardiac phenotype ismaladaptive and inevitably decompensates, manifestingas heart failure. Cardiac remodeling is a determinant ofclinical course and indicates an ominous prognosis...
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Dallabrida et al. (2002) studied this question.