Key result
Peroxynitrite inhibits Coxsackievirus replication by approximately 1,000-fold in vitro by preventing viral RNA entry, while scavenging peroxynitrite in vivo increases viral replication.
p-value: p=<0.01
Peroxynitrite serves as an endogenous antiviral effector against Coxsackievirus infection by preventing viral RNA entry into host cells.
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May inform antiviral strategies in coxsackievirus models; leaves open human translation and therapeutic targeting.
Padalko et al. (2004) studied Coxsackievirus B3 (CVB3) infection. Peroxynitrite and Guanidinoethyl disulfide (GED) vs. Untreated control was evaluated on Viral replication (plaque-forming units) (p=<0.01). Peroxynitrite inhibits Coxsackievirus replication by approximately 1,000-fold in vitro by preventing viral RNA entry, while scavenging peroxynitrite in vivo increases viral replication.
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