A mild and straightforward synthetic protocol for construction of a furan skeleton promoted by Yb(OTf)3 from β-ketothioamides and arylglyoxals has been developed at room temperature. Importantly, this protocol involves a tandem sequence that includes aldol condensation, N-cyclization, ring opening, O-cyclization, S-cyclization, and Eschenmoser sulfide contraction.
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Li et al. (2015) studied this question.
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