Key result
Treatment of gastrointestinal muscles with calcium chelators (EGTA or EDTA) in Ca-free solutions induces rhythmic prolonged potentials and depolarization due to nonspecific reduction in resistance.
Population
Stomach muscles of skate, toad, or frog or intestinal muscle of cat
Design
Preclinical
Authors
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May inform GI electrophysiology mechanisms; leaves open translation to human physiology or therapy.
Calcium chelation in gastrointestinal muscles induces rhythmic prolonged potentials, suggesting that when bound calcium is removed, sodium ions may enter rhythmically through channels normally used by calcium.
Prosser et al. (1977) studied this question. Ca-free physiological solutions containing EGTA or EDTA was evaluated on Electrophysiological changes (spontaneous spikes, slow waves, depolarization, prolonged potentials). Treatment of gastrointestinal muscles with calcium chelators (EGTA or EDTA) in Ca-free solutions induces rhythmic prolonged potentials and depolarization due to nonspecific reduction in resistance.
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